Table 6.

Relationships between the baseline eGFR (at age 88 years), the eGFR slope (between age 85 and 88 years) and a combination of these two parameters and changes in the MMSE, GDS and ADL scores between age 88 and 90 years

All participants		eGFR slope per year between 85 and 88 years in ml/min/1.73 m²/year				P for the eGFR slope per year
		>-1	-1 to -2.99	-3 to -4.99	<-5
Mean change in the MMSE score (+SE)
All participants (n=274)	-1.59 (0.22)	-1.30 (0.28)	-1.74 (0.40)	-2.39 (0.63)	-2.55 (1.49)	0.33
eGFR 88 > 60	-1.30 (0.30)	-1.09 (0.35)	-2.31 (0.75)	-2.00 (1.41)	-1.50 (1.5)	0.27
eGFR 88: 45-60	-1.55 (0.32)	-1.42 (0.45)	-1.14 (0.54)	-2.38 (0.99)	-3.14 (1.42)	0.39
eGFR 88 < 45	-2.66 (0.77)	-2.33 (1.71)	-2.62 (0.99)	-2.75 (1.22)	-4.50 (7.50)	0.95
P (trend) for eGFR subgroups	0.13	0.50	0.27	0.92	0.46
Mean change in the GDS score (+SE)
All participants (n=198)	0.68 (0.20)	0.82 (0.30)	0.51 (0.24)	0.70 (0.68)	-0.40 (1.12)	0.76
eGFR 88 > 60	1.05 (0.36)	1.09 (0.45)	1.14 (0.64)	1.00 (1.41)	-1.00 (3.00)	0.86
eGFR 88: 45-60	0.50 (0.24)	0.59 (0.43)	0.37 (0.30)	0.67 (0.56)	0.00 (1.00)	0.95
eGFR 88 < 45	-0.5 (.59)	-0.50 (0.56)	0.10 (0.43)	0.33 (3.93)	/	0.88
P (trend) for eGFR subgroups	0.22	0.43	0.33	0.96	0.72
Mean change in the ADL score (+SE)
All participants (n=274)	3.58 (0.35)	3.88 (0.48)	3.12 (0.64)	3.42 (1.04)	3.0 (1.17)	0.79
eGFR 88 > 60	3.77 (0.56)	4.04 (0.67)	2.95 (1.35)	2.86 (1.67)	2.50 (2.50)	0.86
eGFR 88: 45-60	3.05 (0.59)	3.24 (0.68)	2.57 (0.72)	2.44 (1.62)	3.43 (1.77)	0.89
eGFR 88 < 45	5.05 (1.10)	5.42 (2.18)	4.75 (1.87)	5.88 (1.89)	2.00 (1.00)	0.91
P (trend) for eGFR subgroups	0.12	0.49	0.42	0.39	0.90

Of the 378 participants at age 88 years, 87 died before age 90 and 17 refused to participate further. The GDS scores were not available for 76 participants who had at least once a low MMSE score in the annual measurements between 88 and 90 years old.