Table 3.
Correlation between stem cell mRNA expression of biopsy samples and lung cancer clinical features
| |
Analyzable |
Bmi1 expression |
P* |
CD133 expression |
P* |
CD44 expression |
P* |
Sox2 expression |
P* |
Nanog expression |
P* |
OCT4 expression |
P* |
MSi2 expression |
P* |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| cases | Postive, n(%) | Postive, n(%) | Postive, n(%) | Postive, n(%) | Postive, n(%) | Postive, n(%) | Postive, n(%) | ||||||||
| Age |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| <60 |
57 |
51(89.5) |
0.716 |
48(84.2) |
0.643 |
56(98.2) |
1 |
55(96.5) |
0.496 |
36(63.2) |
0.958 |
47(82.5) |
0.448 |
54(94.7) |
0.618 |
| ≥60 |
55 |
48(87.3) |
|
48(87.3) |
|
54(98.2) |
|
55(100) |
|
35(63.6) |
|
49(89.1) |
|
54(98.2) |
|
| Gender |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Male |
94 |
84(89.4) |
0.436 |
80(85.1) |
1 |
92(97.9) |
1 |
92(97.9) |
1 |
57(60.6) |
0.167 |
79(84.0) |
0.462 |
90(95.7) |
1 |
| Female |
18 |
15(83.3) |
|
16(88.9) |
|
18(100) |
|
18(100) |
|
14(77.8) |
|
17(94.4) |
|
18(100) |
|
| Histology |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| SCLC |
28 |
27(96.4) |
0.007 |
27(96.4) |
0.066 |
26(92.9) |
0.171 |
27(96.4) |
1 |
22(78.6) |
0.068 |
26(92.9) |
0.601 |
27(96.4) |
1 |
| Ad |
17 |
11(64.7) |
|
16(94.1) |
|
17(100) |
|
17(100) |
|
13(76.5) |
|
14(82.4) |
|
16(94.1) |
|
| SCC |
56 |
52(92.9) |
|
43(76.8) |
|
56(100) |
|
55(98.2) |
|
31(55.4) |
|
46(82.1) |
|
54(96.4) |
|
| other |
11 |
9(81.8) |
|
10(90.9) |
|
11(100) |
|
11(100) |
|
5(45.5) |
|
10(90.9) |
|
11(100) |
|
| Stage |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| I~II |
13 |
13(100) |
0.601 |
11(84.6) |
1 |
13(100) |
1 |
13(100) |
1 |
7(53.8) |
0.369 |
10(76.9) |
0.407 |
13(100) |
1 |
| III~IV |
87 |
78(89.7) |
|
74(85.1) |
|
85(97.7) |
|
85(97.7) |
|
58(66.7) |
|
75(86.2) |
|
84(96.6) |
|
| Differentiation |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Well-Moderate |
28 |
21(75) |
0.027 |
21(75) |
0.216 |
28(100) |
1 |
27(96.4) |
0.337 |
12(42.9) |
0.032 |
22(78.6) |
0.537 |
26(92.9) |
0.262 |
| Poor | 55 | 52(94.5) | 48(87.3) | 55(100) | 55(100) | 37(67.3) | 47(85.5) | 54(96.4) |
* chi-square test . Ad = adenocarcinomas, SCC = squamous cell carcinomas, SCLC = small cell lung carcinomas and others = mucoepidermoid carcinoma, malignant mesothelioma or unclarified lung cancer.