Figure 1.

Skin keratin enrichments. Measured skin keratin enrichments for both psoriatic and uninvolved skin from four individuals (a-d), based on deuterium incorporation in alanine, are plotted together with measured body water enrichments. Some individuals were assessed at two anatomical locations (e-f). Deuterium incorporation at the surface of psoriatic skin lags body water levels by only a few days, whereas the lag is much longer in uninvolved skin. Body water enrichment has been demonstrated to be related to alanine enrichment by a factor of 2.7 and has been plotted here using that correlation.