Table 1.
Uninvolved skin | # of unique peptides | total peptide count | mol wt (Da) | peptide count/mol wt x 103 |
---|---|---|---|---|
Keratin 10 |
34 |
91 |
58827 |
1.55 |
Keratin 1 |
37 |
95 |
66039 |
1.44 |
Keratin 2 |
34 |
66 |
65433 |
1.01 |
Keratin 6A |
10 |
24 |
60045 |
0.40 |
Keratin 77 (Keratin 1B) |
16 |
24 |
61801 |
0.39 |
Keratin 5 |
11 |
20 |
62378 |
0.32 |
Keratin 14 |
5 |
7 |
51622 |
0.14 |
Glycine-N-acyltransferase isoform b |
2 |
2 |
18506 |
0.11 |
Keratin 6 irs4 |
3 |
6 |
57865 |
0.10 |
Glyceraldehyde-3-phosphate dehydrogenase |
2 |
3 |
36053 |
0.08 |
Keratin 9 |
4 |
5 |
62064 |
0.08 |
Keratin 5b |
3 |
4 |
56866 |
0.07 |
Transglutaminase 3 precursor |
2 |
2 |
76731 |
0.03 |
Psoriatic skin |
# of unique peptides |
total peptide count |
mol wt (Da) |
peptide count/mol wt x 103 |
Keratin 6A |
58 |
191 |
60045 |
3.18 |
Keratin 10 |
46 |
147 |
58827 |
2.50 |
Keratin 1 |
50 |
128 |
66039 |
1.94 |
Keratin 14 |
36 |
92 |
51622 |
1.78 |
Keratin 2 |
34 |
81 |
65433 |
1.24 |
Keratin 5 |
29 |
58 |
62378 |
0.93 |
Keratin 17 |
19 |
44 |
48106 |
0.91 |
Keratin 16 |
22 |
46 |
51268 |
0.90 |
Histone cluster 4 |
4 |
8 |
11367 |
0.70 |
S100 calcium-binding protein A8 |
3 |
7 |
10834 |
0.65 |
Serine (or cysteine) proteinase inhibitor, clade B, member 4 |
6 |
14 |
44854 |
0.31 |
Pyruvate kinase, muscle isoform 2 |
9 |
18 |
58062 |
0.31 |
Junction plakoglobin | 12 | 22 | 81745 | 0.27 |
Proteins observed by peptide mass spectrometry from uninvolved and psoriatic skin of a single patient. For each protein the number of unique peptides and the total peptide count, which includes multiple observations of the same peptide, are listed. The peptide count has been divided by the molecular weight and proteins are listed in order of the resulting product. All 13 proteins identified from the uninvolved skin of this individual are listed together with the first 13 (of 66 total) proteins seen in psoriatic skin.