Table 4.

Biochemical and BMD data in the genotypes of the G to A in the 5′ UTR polymorphism of the SHBG gene

Clinical data	G to A at 5′UTR (rs1799941) N=207			Asp356Asn (rs6259) N=199
	GG	GA+AA	P	Asp	Asp+Asn	P
BMD (g/cm2)	(N=124)	(N=83)		(N=150)	(N=45)
Spine	0.952 ± 0.01	0.939 ± 0.02	0.51	0.959 ± 0.01	0.912 ± 0.02	0.05
Total femur	0.867± 0.01	0.831 ± 0.01	0.02	0.869± 0.01	0.814 ± 0.02	0.004*
Femoral Neck	0.713± 0.01	0.694 ± 0.01	0.19	0.718± 0.01	0.678 ± 0.01	0.03
Trochanter	0.652 ± 0.01	0.641 ± 0.01	0.39	0.655 ± 0.01	0.624 ± 0.01	0.05
Intertrochanteric	1.048 ± 0.01	0.980 ± 0.02	0.001*	1.044 ± 0.01	0.966 ± 0.02	0.002*
Biochemical (N=161)	(N=99)	(N=62)		(N=123)	(N=38)
Estradiol (pmol)	53.24±1.78	49.32±2.36	0.18	51.49±1.62	53.58±2.95	0.54
SHBG (nmol)	133.7±7.4	143.9±9.3	0.4	138.9±6.1	144.9±11.0	0.77
FEI (pmol/nmol)	0.543±0.04	0.411±0.05	0.04	-0.91±0.05	-0.96±0.09	0.62
Urine NTx	96.02±7.56	87.81±10.52	0.53	91.23±7.24	108.19±12.82	0.25

BMD comparisons by analysis of covariance (ANCOVA) adjusted for age, body mass index (BMI), years since menopause (YSM), average daily calcium intake; and FEI comparison adjusted for YSM.

^*significant P value <0.00625