Figure 2.

Coregulated genes can be used to predict transcriptional regulation of T cell activation. Enrichment for genes in activated CD8⁺ T cell clusters (identified in Fig. 1) in the context of fine modules of coregulated genes identified by the ImmGen Consortium, for genes encoding selected regulators of T cells (key) predicted through the use of the Ontogenet algorithm¹⁸ based on enriched modules (Supplementary Fig. 4), ‘curated’ by relevance to T cell biology and in order of predicted weight, for which genes with a ‘weight’ of 0 do not contribute to the regulatory program of that cell population.