Table 1. Human kinase genes identified important for influenza virus replication in primary screen.

Symbol	Name	Z-score	Log10 TCID50/mL
NPR2	natriuretic peptide receptor B/guanylate cyclase B	2.64	6.5
MAP3K1	mitogen-activated protein kinase kinase kinase 1	2.55	5.7
DYRK3	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3	2.23	5.9
EPHA6	EPH receptor A6	−2.01	3.0
TPK1	thiamin pyrophosphokinase 1	−2.01	3.0
PDK2	pyruvate dehydrogenase kinase, isozyme 2	−2.03	2.7
C9ORF96	chromosome 9 open reading frame 96	−2.16	2.7
EXOSC10	exosome component 10	−2.16	2.7
NEK8*	never in mitosis gene a- related kinase 8	−2.18	2.7
PLK4*	polo-like kinase 4	−2.18	1.7
SGK3	serum/glucocorticoid regulated kinase family, member 3	−2.19	2.7
NEK3	never in mitosis gene a-related kinase 3	−2.22	2.7
PANK4*	pantothenate kinase 4	−2.35	1.7
ITPKB*	inositol 1,4,5-trisphosphate 3-kinase B	−2.35	1.7
CDC2L5	cell division cycle 2-like 5	−2.38	1.7
CDK3	cyclin-dependent kinase 3	−2.40	1.7
CALM2*	calmodulin 2	−2.59	n.v.
PRKAG3	protein kinase, AMP-activated, gamma 3 non-catalytic subunit	−2.59	n.v.
ERBB4	v-erb-a erythroblastic leukemia viral oncogene homolog 4	−2.59	n.v.
ADK	adenosine kinase	−2.59	n.v.
PKN3	protein kinase N3	−2.59	n.v.
HK2*	hexokinase 2	−2.59	n.v.

^*Genes identified important for influenza in a previous screen; n.v., no detectable virus.

List of HPKs with Z scores ±>2.0 identified in primary screen. Positive z-scores indicated anti-viral HPKs while negative z-scores indicate pro-viral HPKs.