Figure 2. Amino acid residue sequence alignment of human PSEN1 and that predicted for guinea pig, rat and mouse.

Residues that are conserved in human and guinea pig but not in the rat, mouse or both are shaded in blue. Rodent residues not conserved in humans are shaded in black. Residues known to be mutated in FAD in human PSEN1 are shown in red text. Only one residue is conserved in guniea pigs (but not mice and/or rats) that is mutated in FAD (S212Y).