Skip to main content
. 2013 Jun 21;8(6):e66235. doi: 10.1371/journal.pone.0066235

Figure 4. PS2V is up-regulated under cholesterol-fed conditions.

Figure 4

Quantitative PCR analysis shows that, in comparison to animals fed a control diet, guinea pigs fed a cholesterol rich diet showed a significant increase in PSEN2 and PS2V transcripts in (A) frontal cortex (p = 0.004; t = 3.429, d.f. = 14 and p<0.0001, t = 6.841, d.f. = 14, respectively) and (B) cerebellum (p<0.005; t = 4.484 and d.f. = 14 and p<0.003, t = 4.763, d.f. = 14, respectively). The fold increase of PS2V levels in these regions was greater than the increase in full length PSEN2 levels [4 fold vs 2 fold in frontal cortex (p = 0.01, t = 2.994, d.f. = 14], and 6 fold vs 2 fold in the cerebellum (p = 0.002, t = 3.733, d.f. = 14)]. Data is represented as fold change from control fed animals. Transcript levels were normalised against RPS16. Data represents ± SEM.