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. 2013 Jun 21;8(6):e66235. doi: 10.1371/journal.pone.0066235

Figure 5. Increased Aβ1-40 levels in the CNS of cholesterol fed guinea pigs.

Figure 5

(A) CSF Aβ1-40 levels (pg/mL) in the cholesterol and control fed diet groups following 12 weeks of feeding. Value is significantly increased over those animals fed the control diet (p = 0.011, t = 2.896, d.f. = 14). (B) Cerebral Aβ1-40 levels (nmol/g wet tissue) in frontal cortex and cerebellum homogenates from animals fed for 12 weeks on a high cholesterol or control diet. Increases are observed in animals fed cholesterol diet in the frontal cortex (p = 0.04, t = 2.204, d.f. = 14) but not in the cerebellum (p = 0.501, t = 0.684, d.f. = 14, ns). Values mean ± SEM.