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. 2013 Jun 21;8(6):e67832. doi: 10.1371/journal.pone.0067832

Table 2. Bioactivity of pure compounds at different doses.

Stimulus Dose (µg) Treatment median (s) Negative control median (s) P Treatment/negative control
EUG 1 1 17.5 24.0 n.s. 0.7
EUG 1 10 22.5 14.0 n.s. 1.6
EUG 1 100 128.0 9.5 <0.01 13.5
EUG 1 1000 192.5 12.0 <0.01 16.0
EUG 2 10 7.5 14.0 n.s. 0.5
EUG 2 100 182.0 9.5 <0.01 19.2
EUG 2 1000 193.5 12.0 <0.01 16.1
EUG 3 10 18.0 14.0 n.s. 1.3
EUG 3 100 80.0 9.5 <0.01 8.4
EUG 3 1000 187.0 12.0 <0.01 15.6
SYR 10 20.0 18.5 n.s. 1.1
SYR 100 184.0 18.5 <0.01 9.9
SYR 1000 195.5 18.0 <0.01 10.9
ADP 1 12.5 12.0 n.s. 1.0
ADP 10 166.0 16.5 <0.01 10.1
ADP 100 192.0 19.5 <0.01 9.8
ADP 1000 197.5 16.5 <0.01 12.0
CAT 1 12.0 12.0 n.s. 1.0
CAT 10 53.5 12.0 <0.01 4.5
CAT 100 193.0 12.0 <0.01 16.1
CAT 1000 193.5 9.5 <0.01 20.4
MCA 1 13.0 15.0 n.s. 0.9
MCA 10 195.5 15.0 <0.01 13.0
MCA 100 190.5 15.0 <0.01 12.7
MCA 1000 192.0 15.0 <0.01 12.8
ECA 1 16.5 9.0 <0.05 1.8
ECA 10 185.5 9.0 <0.01 20.6
ECA 100 192.5 9.0 <0.01 21.4
ECA 1000 196.5 9.0 <0.01 21.8
DMB 10 12.5 9.5 n.s. 1.3
DMB 100 12.5 9.5 n.s. 1.3
DMB 1000 196.0 9.5 <0.01 20.6
DMT 10 7.0 8.5 n.s. 0.8
DMT 100 106.0 8.5 <0.01 12.5
DMT 1000 199.5 8.5 <0.01 23.5
DMS 10 11.5 10.0 n.s. 1.2
DMS 100 188.5 12.5 <0.01 15.1
DMS 1000 200.0 10.0 <0.01 20.0
ADB 10 28.5 10.0 <0.05 2.9
ADB 100 184.5 16.5 <0.01 11.2
ADB 1000 194.0 10.0 <0.01 19.4
GUA 100 13.0 13.0 n.s. 1.0
GUA 1000 51.5 12.5 <0.01 4.1
MMP 10 10.5 12.0 n.s. 0.9
MMP 100 63.0 8.5 <0.01 7.4
MMP 1000 200.5 10.0 <0.01 20.1
EGU 10 11.5 10.0 n.s. 1.2
EGU 100 184.0 8.5 <0.01 21.6
EGU 1000 181.5 14.0 <0.01 13.0
MVP 10 22.0 10.0 <0.05 2.2
MVP 100 148.0 12.5 <0.01 11.8
MVP 1000 191.5 10.0 <0.01 19.2
MAN 100 17.0 24.5 n.s. 0.7
MAN 1000 8.5 14.0 n.s. 0.6
EAN 100 11.0 14.0 n.s. 0.8
EAN 1000 22.5 14.0 n.s. 1.6
VAN 100 16.5 8.5 <0.05 1.9
VAN 1000 182.5 10.0 <0.01 18.3
EST 100 14.0 9.0 n.s. 1.6
EST 1000 181.5 12.5 <0.05 14.5

P” indicates the statistical significance of the difference between treatment and negative control (n.s.  =  no statistically significant difference). “Treatment/negative control” represents the ratio between the treatment and negative control medians. The results of three independent replicates of eugenol from [23] are reported as a reference (EUG 1, EUG 2, EUG 3).