Table 3. Comparison of HCC patients with and without the pre-S deletion mutants of HBV.
| Without Pre-S deletion (n = 143) | With Pre-S deletion (n = 73) | p | |
| Age (years) | 58; 46–69 | 54; 46–64 | 0.500 |
| Sex (male/female) (%) | 123/20 (86/0%/14.0%) | 65/8 (89.0%/11.0%) | 0.680 |
| Albumin (g/dL)* | 4.1;3.9–4.4 | 4.0; 3.7–4.2 | 0.018 |
| Total bilirubin (mg/dL)* | 0.9; 0.7–1.2 | 0.9; 0.7–1.3 | 0.847 |
| ALT (U/L)* | 42; 27.5–65.6 | 49; 39–74 | 0.084 |
| AST (U/L)* | 42.5; 28–62.5 | 51; 33–79.5 | 0.104 |
| Alk-P (U/L)* | 84; 70.5–107.0 | 97; 72.5–118.5 | 0.359 |
| GGT (U/L)* | 38; 26–70 | 53; 23–133 | 0.008 |
| ICG-15R (%)* | 11; 6–16 | 10; 7–17 | 0.735 |
| Platelet (/mm3)* | 156000; 125000–199000 | 148000; 98000–209000 | 0.849 |
| PT INR* | 1.01; 0.96–1.06 | 1.00; 0.94–1.12 | 0.571 |
| HBVDNA(copies/mL)* | 4.85×105; 3.67×104–1.08×107 | 1.61×106; 9.95×104–1.51×107 | 0.055 |
| HBsAg (IU/mL)* | 896.3; 339.5–1732.4 | 1127.5; 405–2101 | 0.297 |
| HBeAg (yes/no) (%) * | 10/119(7.8%/92.2%) | 15/53(22.1%/77.9%) | 0.008 |
| Genotype B/C (%) | 98/44 (69.0%/31.0%) | 33/40 (45.2%/54.8%) | 0.001 |
| Pre-core (G1896A) mutation (yes/no) (%)* | 88/42 (67.7%/32.3%) | 40/28 (58.8%/41.2%) | 0.279 |
| BCP (A1762T, G1764A) mutation (yes/no) (%)* | 83/47 (63.8%/36.2%) | 52/16 (76.5%/23.5%) | 0.099 |
| Tumor size (cm) | 3.4; 2.5–6.0 | 3.0; 2.1–6.0 | 0.191 |
| Multi-nodularity/single tumor (%) | 57/86 (39.9%/60.1%) | 25/48 (34.2%/65.8%) | 0.512 |
| Macroscopic venous invasion (yes/no) (%)* | 21/121 (14.8%/85.2%) | 12/61 (16.4%/83.6%) | 0.906 |
| AFP (ng/ml) | 20.8; 6.7–752.3 | 50.6; 12.1–803.0 | 0.343 |
| Cut margin ≤1/>1 cm (%)* | 101/42 (70.6%/29.4%) | 45/27 (62.5%/37.5%) | 0.294 |
| Cirrhosis (yes/no) (%)* | 51/86 (37.2%/62.8%) | 40/30 (57.1%/42.9%) | 0.010 |
| Edmondson grading (I–II/III–IV) (%)* | 47/91 (34.1%/65.9%) | 18/53 (25.4%/74.6%) | 0.258 |
| Microscopic venous invasion (yes/no) (%)* | 93/49 (65.5%/34.5%) | 47/26 (64.4%/35.6%) | 0.992 |
| BCLC (A/B/C) (%) | 84/40/14 (59.6%/28.4%/12.1%) | 45/16/11 (62.5%/22.2%/15.3%) | 0.566 |
*
missing data at the time of resection surgery for this parameter.
Continuous variables are expressed as median; 25 and 75 percentiles.
Abbreviations: ALT, alanine aminotransferase; AST, aspartate aminotransferase; Alk-P, alkaline phosphatase; GGT, gamma-glutamyltransferase; ICG-15R, indocyanine green retention rate at 15 minutes; PT, prothrombin time; INR, international normalized ratio; HBsAg, hepatitis B surface antigen; BCP, basal core promoter; BCLC, the Barcelona-Clinic Liver Cancer.