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. Author manuscript; available in PMC: 2014 May 10.
Published in final edited form as: Science. 2013 Mar 28;340(6133):711–716. doi: 10.1126/science.1234150

Table 1.

Binding of GL and mature (Mat) Abs to gp120 and eOD variants. Values represent KDs in nM measured by SPR. Binding to GL antibodies highlighted in red.

Antigen Antibody

VRC01 12A12 3BNC60 NIH45-46 PGV04 PGV19 PGV20 VRC-CH31
GL Mat GL Mat GL Mat GL Mat GL Mat GL Mat GL Mat GL Mat

WT CD4Binding Site Core.HXB2 >105 5 >105 6 >105 36 >105 35 >105 48 >105 20 >105 19 >105 47
eOD Base N276D >105 5 >105 380 >105 4,100 >105 14 >105 110 >105 3,100 17,000 16 >105 30,000

Modified CD4 Binding Site Core.BaL-GT1 1,800 0.5 3,200 1 16,400 4 >105 0.6 >105 170 25 14 5,500 4 35,000 1,800
eOD-GT1 44,000 1 >105 2,300 >105 83 >105 3 >105 4 7,800 1,000 1,100 10 >105 >105
eOD-GT6 44 2 2,000 400 14,000 200 410 4 52,000 10 19 88 3 6 28,000 29,000