Table 1.
Antigen | Antibody | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| |||||||||||||||||
VRC01 | 12A12 | 3BNC60 | NIH45-46 | PGV04 | PGV19 | PGV20 | VRC-CH31 | ||||||||||
GL | Mat | GL | Mat | GL | Mat | GL | Mat | GL | Mat | GL | Mat | GL | Mat | GL | Mat | ||
| |||||||||||||||||
WT CD4Binding Site | Core.HXB2 | >105 | 5 | >105 | 6 | >105 | 36 | >105 | 35 | >105 | 48 | >105 | 20 | >105 | 19 | >105 | 47 |
eOD Base N276D | >105 | 5 | >105 | 380 | >105 | 4,100 | >105 | 14 | >105 | 110 | >105 | 3,100 | 17,000 | 16 | >105 | 30,000 | |
| |||||||||||||||||
Modified CD4 Binding Site | Core.BaL-GT1 | 1,800 | 0.5 | 3,200 | 1 | 16,400 | 4 | >105 | 0.6 | >105 | 170 | 25 | 14 | 5,500 | 4 | 35,000 | 1,800 |
eOD-GT1 | 44,000 | 1 | >105 | 2,300 | >105 | 83 | >105 | 3 | >105 | 4 | 7,800 | 1,000 | 1,100 | 10 | >105 | >105 | |
eOD-GT6 | 44 | 2 | 2,000 | 400 | 14,000 | 200 | 410 | 4 | 52,000 | 10 | 19 | 88 | 3 | 6 | 28,000 | 29,000 |