Table 3.

Independent predictors of ACS during the follow-up (n=273)

	OR (95% CI)	P value
History of ACS or pneumonia at recruitment	5.0 (2.3-11.0)	<0.0001
Age (years)	0.91 (0.84-0.97)	0.007
Baseline chronic transfusion program	1.7 (0.7-4.4)	0.3
Baseline hydroxyurea treatment	1.4 (0.7-2.9)	0.4

Variables entered into model include: genotype, age, gender, hydroxyurea treatment, number of blood transfusions, number of severe pain in last year, history of asthma, history of ACS or pneumonia at recruitment, hemoglobin, MCV, WBC (natural log), platelet (square root), LDH (natural log), ferritin (natural log), tricuspid regurgitation velocity, mitral valve E/Etdi. Hydroxyurea treatment and chronic transfusion program were forced into the model.

Area Under ROC Curve = 0.73, P value for goodness of fit = 0.8