Table 3.

Demographics and Clinical Characteristics of MDA5 Positive and Negative DM Patients

	MDA5-positive (N = 11)	MDA5-negative (N = 149)	p-value
	N (%)	N (%)
Demographics
Gender			0.94
Male	3 (27.3)	39 (26.2)
Female	8 (72.7)	110 (73.8)
Race			0.24
Caucasian	8 (72.7)	124 (83.2)
African American	2 (18.2)	17 (11.4)
Asian	0 (0)	6 (4.0)
Other	1 (9.1)	2 (1.3)
Mean age at diagnosis, y	41.4	44.9	0.48
Median disease duration, m	24.5	26.3	0.9
Clinical Features
Gottron’s Papules/Sign	11(100)	111 (75)†	0.055
Heliotrope rash	9 (81.8)	71 (48.0)†	0.03
Weakness	6 (54.5)	138 (93.2)†	<0.001
Fever	5 (45.5)	24 (16.4)¥	0.017
Inflammatory Arthropathy	9 (81.8)	39 (26.7)¥	<0.001
Raynaud’s Phenomenon	5 (45.5)	44 (30.3)§	0.3
Mechanic’s Hands	9 (81.8)	28 (19.0)‡	<0.001
Interstitial Lung Disease	8 (72.7)	17 (11.4)	<0.001
Calcinosis	3 (27.3)	18 (12.1)	0.15

Clinical data was not available for every MDA5-negative patient. Where indicated, n is less than 149.

^†n = 148;

^‡n= 147;

^¥n = 146;

^§n = 145