Cross-sectional areas of intima (A), media (B) index (intimal/medial area) (C) and photomicrographs of haematoxylin-eosin–stained rabbit carotid arteries (D) are shown. Intimal area and index were significantly increased in collared arteries in placebo group, *** P<0.001, n=8, sham vs. collar, two way ANOVA, Bonferroni posttest). Lacidipine treatment significantly inhibited the increase in intimal or intimal/medial area (+ ++ P<0.001, n=6, placebo vs. lacidipine, two way ANOVA, Bonferroni posttest). Collar or lacidipine treatment did not alter the medial cross-sectional area.