Table 2.

Geometric mean ratios (treatment A/treatment B) and 90 % confidence limits of the primary pharmacokinetic and pharmacodynamic variables of warfarin (n = 13)

Variable	Geometric mean ratio (90 % confidence limits)
C max of S-warfarin	0.99 (0.86, 1.14)
AUC 0–∞ of S-warfarin	0.99 (0.89, 1.09)
C max of R-warfarin	1.00 (0.88, 1.13)
AUC0–∞ of R-warfarin	1.05 (0.95, 1.16)
AUCINR	0.99 (0.82, 1.19)

AUC area under the plasma concentration–time curve, C _max maximum plasma concentration_, INR international normalized ratio