Fig. 5.

Summary of integrase inhibitor drug-resistance mutations. Mutations are represented by their numeric position and amino acid letter code. The amino acid of the consensus wild-type sequence is represented by letters in the top row, while the amino acids of the mutations are below. Bold and underlining indicates >10- to 20-fold decreased susceptibility (probable contraindication); bold text indicates significant contribution to phenotypic and/or clinical resistance; plain text indicates <5- to 10-fold decreased susceptibility. Refer to table I for a full list of drug name abbreviations and definitions. Adapted from the Stanford University HIV Drug Resistance Database.[40] Cons = consensus wild-type.