. Author manuscript; available in PMC: 2013 Jun 22.

Published in final edited form as: Biochem J. 2012 Feb 1;441(3):789–802. doi: 10.1042/BJ20111626

Table 5. Pro-apoptotic inducers of CerS activity.

bFGF, basic fibroblast growth factor; 4-HPR, 4-hydroxy(phenyl)retinamide.

Inducer	Cell line/experimental system	Reference
Daunorubicin	P388 lymphocytic leukaemia cells	[60]
Doxorubicin	FTC-133 follicular thyroid carcinoma	[97]
Camptothecin	FTC-133 follicular thyroid carcinoma	[97]
TNF-α	Kym-1 rhabdomyosarcoma cells	[98]
Fenretinide (4-HPR)	CHLA-90 neuroblastoma cells	[99]
UV light (UV-B)	Human keratinocytes	[100]
Vascular endothelial growth factor receptor tyrosine kinase inhibitor SU5416	Mouse lung	[101]
¹²⁵I-Deoxyuridine	Bovine aortic endothelial cells	[102]
Phorbol ester	CWR22-Rv1 prostate cancer cells	[103]
	LNCaP prostate cancer cells	[104]
IR	bFGF-treated C57BL6 mice	[105]
	HeLa cervical carcinoma cells	[71]
IR ± phorbol ester	LNCaP prostate cancer cells	[106]