. Author manuscript; available in PMC: 2013 Jun 22.

Published in final edited form as: Biochem J. 2012 Feb 1;441(3):789–802. doi: 10.1042/BJ20111626

Table 6. Selected studies demonstrating inhibition of cell death by FB₁.

N/D, not detected.

Death inducer	Cell line/system	FB₁ inhibits ceramide	FB₁ inhibits death	Reference
Receptor-mediated
TNF-α	MCF-7 breast carcinoma cells	+	+	[107]
	L929 fibroblasts	+	+	[107]
	HL-60 promyelocytic leukaemia cells	+	+	[108]
TNF-α/cycloheximide	Cerebral endothelial cells	+	+	[109]
B-cell receptor cross-linking	Ramos B-cells	+	+	[110]
T-cell receptor cross-linking	T-cell hybridoma	N/D	+	[111]
Cancer chemotherapeutic agents
Camptothecin	4B1 (human Fas-expressing L929 mouse fibroblasts)	N/D	+	[112]
	FTC-133 follicular thyroid carcinoma cells	+	+	[97]
Doxorubicin	MCF-7 breast carcinoma cells	N/D	+	[113]
	Rat primary astrocytes	N/D	+	[114]
	FTC-133 follicular thyroid carcinoma cells	+	+	[97]
Daunorubicin	P388 lymphocytic leukaemia cells	+	+	[60]
	Hen follicular granulosa cells	N/D	+	[115]
Etoposide	MOLT4 leukaemia cells	+	+	[116]
Fenretinide (4-HPR)	HL-60 promyelocytic leukaemia	+	+	[117]
	Endothelial cells	+	+	[118]
Fludarabine	Chronic B-cell leukaemia	+	+	[119]
	LNCaP prostate cancer cells	+	+	[120]
Inostamycin	Ms-1 small cell lung carcinoma cells	+	+	[121]
Oxaliplatin + SK inhibitor	RKO colon carcinoma cells	+	+	[122]
Vascular endothelial growth factor inhibitor SU5416	Mouse lung	N/D	+	[101]
IR and non-IR
γ-Irradiation	Mouse colonic crypts	N/D	+	[105]
	Human lymphoblasts	+	+	[123]
	LNCaP prostate cancer cells	+	+	[106]
¹²⁵I-Labelled 5-iodo-29-deoxyuridine	Bovine aortic endothelial cells	+	+	[102]
UV-B	Human keratinocytes	+	+	[100]
UV-C	Hen follicular granulosa cells	N/D	+	[115]

Table 6. Selected studies demonstrating inhibition of cell death by FB1.