Table 1. Individual pharmacokinetic parameters of TQD after single dose administration at doses of 4, 6 and 8 mg/kg BW (n=5 per dose group).

Dose group (mg/kg BW)	Subject number	Infusion duration (h)	Dose (mg)	Cmax (mg/l)	tmax(h)	AUC0-n (mg*h/l)	CL (l/h)	t½(h)	Vss (l)
4	1	1.72	388	1.31	1.29	14.48	9.27	43	558
4	2	1.38	312	1.21	1.38	11.39	11.29	33	530
4	3	1.45	328	1.12	1.45	12.71	7.39	55	571
4	4	1.55	348	1.47	1.55	17.26	9.22	30	384
4	5	1.40	316	1.13	1.40	13.54	10.11	31	445
6	6	1.83	414	2.03	1.83	19.96	13.53	16	312
6	7	2.23	504	1.81	2.23	18.00	11.35	35	559
6	8	2.80	630	1.13	2.80	19.68	13.56	34	645
6	9	2.45	552	1.64	2.45	20.12	13.99	26	509
6	10	2.45	552	1.31	2.45	16.16	15.15	33	680
8	11	2.82	632	1.59	2.82	23.61	15.71	21	453
8	12	2.42	544	1.92	2.42	18.83	15.41	25	521
8	13	2.28	512	1.05	2.28	14.77	16.21	30	667
8	14	2.70	608	1.87	2.70	21.81	20.85	14	380
8	15	2.67	604	1.66	2.26	16.64	22.15	21	616