FIG. 3.

Effect of early drug treatment on in vitro engineered cartilage formation. Gross view, histology, and safranin O staining (A) of in vitro engineered cartilages without or with drug treatment at various drug concentrations at day-2 post-cell seeding and the quantitative analyses of wet weight (B) and tissue volume (C). 2D represents day 2, and 1×, 2×, and 4×, respectively, represent 1 time, 2 times, and 4 times of drug concentrations. Bar=100 μm. The symbol *represents statistically significant difference from the control group (p<0.05, n=4). Color images available online at www.liebertpub.com/tec