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. 2013 Jun 15;30(12):1035–1052. doi: 10.1089/neu.2013.2915

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Copyright 2013, Mary Ann Liebert, Inc.

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FIG. 13. — Transplantation of human glial restricted progenitors (hGRP) creates a permissive environment that supports the regeneration of injured sensory axons. hGRP were differentiated for 10 days with basic fibroblast growth factor (bFGF), bone morphogenetic protein 4 (BMP-4), or ciliary neurotrophic factor (CNTF), harvested and acutely grafted into the injured spinal cord. Sections were analyzed for the regeneration of sensory axons five weeks post-transplant by tracing with cholera toxin b subunit (CTB) and Human Nuclear Antigen (HuNu) antibodies. Panels A–D (bFGF), E–H (BMP-4), and I–L (CNTF) show immunohistology for HuNu and CTB and reveal that CTB-labeled regenerating axons derived from anterograde labeling of long ascending sensory axonal projections (derived from tracing of the sciatic nerve) regenerate along transplanted hGRP, highlighting the permissive nature of hGRP and embryonic astrocytes derived from hGRP. Scale bar=100 μm.