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. 2013 Jun 15;30(12):1035–1052. doi: 10.1089/neu.2013.2915

FIG. 8.

FIG. 8.

Quantitative and statistical analysis of phenotypic reversal: Ki67. The percentage of Ki67-positive cells at day 14 were calculated relative to cultures maintained in the original factor for 14 days. Panels A and B show the percentage of cells staining positive for Ki67 relative to the total number of cells. Panel A shows the quantitative analysis for glial restricted progenitors (GRP) differentiated with bone morphogenetic protein 4 (BMP-4) and indicates increased levels of the Ki67 marker on challenge with basic fibroblast growth factor (bFGF). Panel B shows the quantitative analysis for GRP differentiated with CNTF and indicates reduced levels of the Ki67 marker on challenge with BMP-4 and an increase upon challenge with bFGF. Error bars represent 1 standard error. Dashed lines have been added to provide reference to cultures of GRP differentiated for 14 days with an original treatment. Stars summarize the statistical analysis showing the significant changes among the groups compared to cultures grown for 14 days in the initial factor. Statistical significance was set at p<0.01 for all comparisons.