Table 3.
Effect of Methylphenidate (MPH) Treatment on Parent Behavioral Ratings
| |
MPH dose level |
Effect of MPH dose level |
|
|||||
|---|---|---|---|---|---|---|---|---|
| Parent behavioral instrument (Means/SD) | Placebo | Low dose MPH | Medium dose MPH | High dose MPH | ANOVA p-value | Linear trend p-value | Quadratic trend p-value | Source of significance |
| Conners Parent Rating Scale-Revised (CPRS-R) | ||||||||
| CGI: Restless-Impulsive | 69.5 | 63.9 | 60.9 | 58.2 | 0.000 | 0.000 | 0.429 | P:M, P:H. L:H |
| (12.6) | (10.3) | (9.8) | (9.8) | |||||
| CGI: Emotional Lability | 57.3 | 54.2 | 54.5 | 49.3 | 0.089 | 0.020 | 0.573 | (n/a) |
| (15.8) | (14.0) | (13.6) | (10.8) | |||||
| CGI: Total | 66.8 | 61.9 | 59.9 | 55.8 | 0.001 | 0.000 | 0.818 | P:M, P:H. L:H |
| (12.7) | (11.7) | (9.8) | (9.3) | |||||
| Oppositional | 59.2 | 53.1 | 53.8 | 49.8 | 0.021 | 0.010 | 0.620 | None pairwise |
| (16.0) | (15.3) | (12.4) | (11.4) | |||||
| Cognitive problems/Inattention | 70.3 | 67.7 | 63.9 | 60.0 | 0.001 | 0.000 | 0.818 | P:M, P:H. L:H |
| (12.8) | (11.6) | (12.5) | (11.7) | |||||
| Hyperactivity | 70.8 | 62.6 | 62.1 | 58.3 | 0.000 | 0.000 | 0.335 | P:M, P:H |
| (15.2) | (12.2) | (12.0) | (10.2) | |||||
| ADHD Index | 70.1 | 64.9 | 62.3 | 59.9 | 0.000 | 0.000 | 0.454 | P:M, P:H |
| (11.9) | (9.3) | (10.0) | (10.5) | |||||
| SNAP-IV-Parent | ||||||||
| Inattentive | 17.8 | 15.0 | 14.0 | 12.7 | 0.000 | 0.000 | 0.463 | P:M, P:H |
| (5.8) | (6.1) | (4.8) | (6.0) | |||||
| Hyperactive | 13.8 | 11.0 | 8.8 | 8.9 | 0.001 | 0.000 | 0.146 | P:M, P:H |
| (6.6) | (6.5) | (5.8) | (5.3) | |||||
| Combined | 31.6 | 26.0 | 22.8 | 21.6 | 0.000 | 0.000 | 0.245 | P:M, P:H |
| (11.0) | (11.1) | (9.6) | (9.6) | |||||
| ACTeRS Parent | ||||||||
| Attention | 10.9 | 12.4 | 13.4 | 14.0 | 0.068 | 0.001 | 0.665 | P:H |
| (4.7) | (5.3) | (5.0) | (4.2) | |||||
| Hyperactivity | 15.7 | 13.3 | 12.0 | 12.0 | 0.000 | 0.000 | 0.069 | P:M, P:H |
| (4.5) | (4.5) | (4.0) | (4.3) | |||||
| Social Skills | 12.8 | 13.3 | 12.0 | 14.0 | 0.048 | 0.288 | 0.235 | M:H |
| (4.5) | (4.4) | (3.7) | (4.3) | |||||
| Oppositional | 8.4 | 7.8 | 6.8 | 6.6 | 0.035 | 0.021 | 0.596 | P:M |
| (5.3) | (5.6) | (4.0) | (2.6) | |||||
| Aberrant Behavior Checklist | ||||||||
| Irritability | 12.6 | 10.0 | 8.2 | 7.2 | 0.004 | 0.002 | 0.489 | P:H |
| (10.4) | (9.2) | (8.1) | (6.9) | |||||
| Lethargy/Social withdrawal | 9.3 | 7.3 | 8.1 | 8.5 | 0.424 | 0.678 | 0.180 | (n/a) |
| (8.1) | (5.6) | (5.9) | (6.6) | |||||
| Stereotypy | 4.9 | 4.3 | 4.0 | 3.5 | 0.302 | 0.073 | 0.907 | (n/a) |
| (5.4) | (4.5) | (3.8) | (3.8) | |||||
| Hyperactivity | 24.1 | 18.1 | 14.5 | 14.5 | 0.000 | 0.000 | 0.082 | P:M, P:H |
| (13.0) | (10.5) | (7.7) | (9.2) | |||||
| Inappropriate speech | 5.2 | 4.3 | 4.0 | 3.9 | 0.010 | 0.003 | 0.214 | P:M, P:H |
| (3.1) | (3.2) | (3.1) | (3.1) | |||||
| Visual Analogue Scale(VAS) | ||||||||
| VAS Measure (in mm) | 95.6 | 80.9 | 79.6 | 69.0 | 0.006 | 0.005 | 0.666 | P:H |
| (20.2) | (25.2) | (29.1) | (32.1) | |||||
| Social Communication Questionnaire(SCQ) | ||||||||
| SCQ Score | 15.5 | 14.2 | 15.2 | 13.4 | 0.046 | 0.026 | 646 | None pairwise |
| (6.1) | (6.6) | (6.2) | (6.2) | |||||
Bold indicates that there was a statistically significant effect of MPH dose (i.e., p < .05).
CGI, Clinical Global Impressions; ADHD, attention-deficit/hyperactivity disorder; SNAP-IV, Swanson, Nolan, and Pelham Questionnaire, Revised for American Psychiatric Association, Diagnostic and Statistical Manual of Mental Disorders, 4th ed. (DSM-IV); ACTeRS, ADD-H Comprehensive Teacher Rating Scale; P, placebo; L, low dose MPH; M, medium dose MPH; H, high dose MPH.