Table 5.

Effect of Methylphenidate (MPH) Treatment on Clinical Global Impressions (CGI) Ratings

	MPH dose level				Effect of MPH dose level
CGI measure: Mean/SD (Clinician)	Placebo	Low dose MPH	Medium dose MPH	High dose MPH	ANOVA p-value	Linear trend p-value	Quadratic trend p-value	Source of significance
CGI-Severity (DAP)	4.8	4.0	3.8	3.8	0.000	0.001	0.018	P:L, P:M, P:H
	(0.61)	(0.81)	(0.82)	(0.74)
CGI-Improvement (DAP)	4.0	2.8	2.4	2.1	0.000	0.000	0.126	P:L, P:M, P:H
	(0.81)	(1.3)	(1.3)	(1.2)
CGI-Severity (CWS)	4.7	4.0	4.0	3.9	0.000	0.001	0.086	P:L, P:M, P:H
	(0.76)	(0.72)	(0.62)	(0.74)
CGI-Improvement (CWS)	4.1	2.8	2.6	2.0	0.000	0.000	0.218	P:L, P:M, P:H
	(0.95)	(1.4)	(1.3)	(1.0)

Bold indicates that there was a statistically significant effect of MPH dose (i.e., p < .05).

P, placebo; L, low dose MPH; M, medium dose MPH; H, high dose MPH.