FIGURE 6.

Loss of eNOS expression prevents E2-mediated improvements in cardiac function post-AMI. Ethanol-mediated repression of the left ventricular end diastolic area (A) and fractional shortening (B) were significantly worse in eNOS-null mice (eNOS^−/−) compared with WT mice (despite E2 supplementation), indicating that ethanol consumption negatively affects post-AMI myocardial function in female eNOS knockout mice, suggesting a role for eNOS in ethanol-mediated EPC dysfunction. n = 8 mice/group.