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2-MeSADP-induced secretion and TxA2 generation in Pyk2-deficient platelets. Non-aspirin-treated washed platelets from Pyk2−/− mice and Pyk2+/+ littermates were stimulated with 100 nm 2-MeSADP for 3.5 min, and ATP secretion (A) and TxA2 generation (B) were measured. The values are representative of three independent experiments. Data are mean ± S.E. (n = 3). *, p < 0.005.
