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. 2013 May 7;288(25):18439–18447. doi: 10.1074/jbc.M112.405928

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© 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 3. — SIRT6-OKSM iPSC lines can spontaneously differentiate in three germ layers. A, expression of markers for neuroectoderm (Nestin), mesoderm (α-actinin), and endoderm SOX17, (α-fetoprotein). B, DNA microarray data comparing global gene expression profiles of human fibroblasts (FB), SIRT6-iPSCs (S6), and human ESCs (H9). Heat map and hierarchical clustering analysis by Pearson correlation show SIRT6-OKSM-iPSCs to be similar to ESCs. C, scatter plots comparing global gene expression patterns between SIRT6-iPSCs and ESCs. D, scatter plots comparing global gene expression patterns between SIRT6-OKSM-iPSCs and OKSM-iPSCs.