FIGURE 6.

A schematic indicating proposed feedback regulation between miR-766 and SIRT6 expression. In younger subjects, high levels of SIRT6 activity ensure deacetylation at H3K9 at various promoters, including the SEPT6/miR-766 promoter, which results in a lower expression of the microRNA. However, in older subjects, slight changes in expression or activity of SIRT6 may result in higher acetylation (Ac) levels of H3K9 and elevated levels of miR-766, which further reduce the expression of SIRT6.