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Negative net impact of the microRNA machinery on HBV replication in HepG2 cells. A, siRNA-mediated knockdown of Ago2 was verified by real-time RT-PCR and Western blotting. B and C, Ago2 knockdown enhanced the production of both s (HBs) and e (HBe) antigens (B) and increased HBV replication (C). D and E, enhanced HBV replication was also observed after knocking down DGCR8 (D) or Dicer (E). *, p < 0.05; **, p < 0.01; ***, p < 0.001 on the basis of experiments performed in triplicate.
