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. 2012 Nov 12;75(6):1396–1405. doi: 10.1111/bcp.12032

Table 1.

The effects of paracetamol on BP: observational studies

Author n Duration Paracetamol use Cases of HTN Relative risk
Dedier et al.35 51 630 8 years Days per month
None 4037 1.00
1–4 2959 1.07
5–14 1033 1.22
15–21 317 1.31
>22 457 1.2
Curhan et al.36 80 020 2 years Days per month
None 369 1.00
1–4 661 1.19
5–14 229 1.37
15–21 62 1.62
≥22 72 2.00
Kurth et al.38 8 229 14 years Cumulative use over 14 years
<12 1204 1.00*
12–1499 607 0.86 (0.77–0.95)*
1500–2499 87 1.17 (0.93–1.46)*
≥2500 97 1.08 (0.87–1.34)*
Forman et al.39 16 031 2 years Days per week
0 1743 1.00
1 47 1.00
2–3 69 1.00
4–5 36 1.59
6–7 50 1.34
*

Hazard ratio. HTN, hypertension.