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Light transmission platelet aggregometry in healthy subjects and patients with sickle cell disease (SCD) before and after prasugrel treatment. Maximal platelet aggregation, measured by light transmission aggregometry, in response to 5 μm (A) and 20 μm (B) ADP at baseline before prasugrel treatment and following 12 days of prasugrel treatment in healthy subjects (n = 13) and in patients with sickle cell disease (n = 13). 
, baseline; 
, day 12
