Table 2.
Baseline haematology measurements for healthy subjects and patients with sickle cell disease
| Measure | Healthy subjects [n = 13; mean (SD)] | Sickle cell disease [n = 13; mean (SD)] | P value* |
|---|---|---|---|
| Haematocrit (%) | 41 (5) | 24 (3) | <0.001 |
| Haemoglobin (mmol l−1) | 8.7 (1.0) | 5.2 (0/5) | <0.001 |
| Neutrophils (×103 μl−1) | 3.5 (1.5) | 4.5 (1.4) | 0.081 |
| Mean cell volume (fl) | 88.2 (3.4) | 87.2 (15.0) | 0.817 |
| Erythrocyte count (×106 μl−1) | 4.7 (0.5) | 2.8 (0.7) | <0.001 |
| Leucocytes (×103 μl−1) | 6.0 (2.0) | 9.6 (2.7) | <0.001 |
| Lymphocytes (×103 μl−1) | 1.8 (0.5) | 3.6 (1.3) | <0.001 |
| Monocytes (×103 μl−1) | 0.5 (0.1) | 1.2 (0.5) | <0.001 |
| Eosinophils (×103 μl−1) | 0.2 (0.1) | 0.3 (0.2) | 0.095 |
| Basophils (×103 μl−1) | 0.02 (0.04) | 0.04 (0.05) | 0.199 |
| Platelets (×103 μl−1) | 234.6 (50.0) | 375.8 (112.6) | <0.001 |
| Mean platelet volume (fl) | 10.4 (0.7) | 10.1 (0.8) | 0.198 |
| MCHC (mmol l−1-Fe) | 21.1 (0.6) | 21.8 (0.6) | 0.003 |
| Reticulocyte count (×103 μl−1) | 43.6 (28.7) | 252.8 (120.1) | <0.001 |
| Prothrombin time (s) | 11.1 (0.6) | 11.5 (0.7) | 0.099 |
| APTT (s) | 28.1 (1.7) | 25.2 (2.0) | <0.001 |
| Platelet distribution index | 12.2 (1.5) | 11.0 (1.4) | 0.034 |
Abbreviations are as follows: APTT, activated partial thromboplastin time; and MCHC, mean cell haemoglobin concentration.
*
P values are from Student's unpaired t-test.