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Single and repeat dose median plasma semi-log concentration–time profiles for fluticasone furoate (FF; 0–48 h) and vilanterol trifenatate (VI; 0–12 h) after co-administration of ketoconazole or placebo and FF/VI (study 2). 
, single dose FF/VI + placebo; 
, single dose FF/VI + ketoconazole; 
, repeat dose FF/VI + placebo; 
, repeat dose FF/VI + ketoconazole; and 
, lower limit of quantification (LLQ) 10 pg ml–1
