Table 1.
Frequency distribution of AKR1C3 genetic variants (n = 151)
| Genetic variants (SNP) | Genotype frequency | Allele frequency | |||
|---|---|---|---|---|---|
| C/C | C/T | T/T | C | T | |
| Exon 5 508 C>T (rs35575889) | 100% | 0% | 0% | 1.00 | 0 |
| Exon 5 538 C>T (rs34186955) | 100% | 0% | 0% | 1.00 | 0 |
| IVS4–212 C>G (rs1937840) | C/C | C/G | G/G | C | G |
| Chinese | 0% (0/86) | 20% (17/86) | 80% (69/86) | 0.10 | 0.90 |
| Malay | 8% (4/52) | 21% (11/52) | 71% (37/52) | 0.18 | 0.82 |
| Indian | 11% (1/9) | 33% (3/9) | 56% (5/9) | 0.28 | 0.72 |
| Others | 0% (0/4) | 0% (0/4) | 100% (4/4) | 0 | 1.00 |
| Total | 3% (5/151) | 21% (31/151) | 76% (115/151) | 0.14 | 0.86 |
| IVS4+218 G>A (rs1937841) | G/G | G/A | A/A | G | A |
| Chinese | 79% (68/86) | 21% (18/86) | 0% (0/86) | 0.90 | 0.10 |
| Malay | 77% (40/52) | 21% (11/52) | 2% (1/52) | 0.88 | 0.12 |
| Indian | 89% (8/9) | 11% (1/9) | 0% (0/9) | 0.94 | 0.06 |
| Others | 100% (4/4) | 0% (0/4) | 0% (0/4) | 1.00 | 0 |
| Total | 79% (120/151) | 20% (30/151) | 1% (1/151) | 0.89 | 0.11 |