Table 3.
Frequency distribution of ABCB1, CBR3 and SLC22A16 genetic variants (n = 151)
| Genetic variants (SNPs) | Genotype frequency | Allele frequency | |||||||
|---|---|---|---|---|---|---|---|---|---|
| ABCB1 | |||||||||
| G2677T/A* | GG | GT | GA | TT | AA | TA | G | T | A |
| 37 (25%) | 56 (37%) | 18 (12%) | 23 (15%) | 4 (3%) | 12 (8%) | 0.49 | 0.38 | 0.13 | |
| IVS26+59 T>G | TT | TG | GG | T | G | ||||
| 56 (37%) | 64 (42%) | 31 (21%) | 0.37 | 0.63 | |||||
| CBR3 | |||||||||
| G11A† | GG | GA | AA | G | A | ||||
| 36 (37%) | 30 (30%) | 33 (33%) | 0.52 | 0.48 | |||||
| G730A* | GG | GA | AA | G | A | ||||
| 31 (21%) | 56 (37%) | 63 (42%) | 0.39 | 0.61 | |||||
| SLC22A16 | |||||||||
| T312C* | TT | TC | CC | T | C | ||||
| 63 (42%) | 65 (43%) | 22 (15%) | 0.64 | 0.36 | |||||
| T1226C* | TT | TC | CC | T | C | ||||
| 145 (97%) | 5 (3%) | 0 (0%) | 0.98 | 0.02 | |||||
| T755C* | TT | TC | CC | T | C | ||||
| 123 (82%) | 27 (18%) | 0 (0%) | 0.91 | 0.09 | |||||
*
Genotype data are available for only 150 patients because of failed assays in one patient.
†
Genotype data are available for only 99 patients of the first study cohort.