Figure 1.

Urinary 6β-hydroxycortisol : cortisol and plasma 4β-hydroxycholesterol : cholesterol (× 10⁴) in adult healthy volunteers before and after 2 weeks of rifampicin treatment (500 mg day⁻¹, upper panels; 100 mg day⁻¹, middle panels; 20 mg day⁻¹, lower panels). The 6β-hydroxycortisol : cortisol ratios were determined in 12 h urine collections. P values from analysis using Wilcoxon matched pairs test. 6β-OH-F: 6β-hydroxycortisol; F: cortisol; 4β-OH-chol: 4β-hydroxycholesterol; chol: cholesterol