Table 3.

Meta-analysis of SNPs for association with plasma adiponectin levels.

SNP	Positiona	location	coding change	Allelesb	IRASFSc						AA-DHSd						Meta-analysis
					MAFe	1 / 1f	1 / 2f	2 / 2f	p-valueh	β	MAFe	1 / 1f	1 / 2f	2 / 2f	p-valueh	β	p-valueh	β
rs1648707	188034405	5′		A / Cg	0.39	9.25 ± 4.73	9.19 ± 5.09	8.48 ± 5.10	0.017	−0.072	0.44	8.75 ± 9.3	8.20 ± 5.8	7.62 ± 4.3	0.40	0.042	0.01657	−0.02158
rs822387	188038731	5′		T / C	0.33	9.43 ± 5.10	8.88 ± 4.96	7.68 ± 4.95	0.23	−0.042	0.36	9.05 ± 8.0	7.40 ± 5.2	9.43 ± 7.8	0.98	0.0016	0.3445	−0.0236
rs17300539	188042154	5′		G / A	0.028	8.98 ± 5.25	11.16 ± 5.21	-	0.0018	0.32	0.013	8.35 ± 6.9	7.00 ± 3.3	--	0.75	−0.060	0.02231	0.156023
rs822390	188045592	intron 1		T / G	0.071	8.94 ± 5.42	10.32 ± 5.06	8.13 ± 2.94	0.24	0.10	0.036	8.24 ± 6.6	11.46 ± 10.2	--	0.071	0.26	0.03487	0.179431
rs16861209	188045808	intron 1		C / A	0.14	8.90 ± 5.20	9.26 ± 4.51	9.16 ± 5.61	0.034	0.086	0.18	8.37 ± 7.2	8.39 ± 6.3	6.10 ± 2.4	0.70	0.025	0.05942	0.058759
rs822391	188046497	intron 1		T / C	0.031	8.97 ± 5.11	9.49 ± 4.34	8.13 ± 2.94	0.67	−0.031	0.038	8.11 ± 6.6	10.76 ± 10.0	6.38 ± 0.6	0.24	0.13	0.6834	0.04213
rs822394	188049422	intron 1		C / A	0.029	8.93 ± 5.06	9.92 ± 4.62	5.87 ± 3.14	0.88	−0.010	0.034	8.13 ± 6.6	11.08 ± 10.1	--	0.11	0.22	0.3712	0.092191
rs2241766	188053586	exon 2	G15G	T / G	0.031	8.97 ± 5.04	9.29 ± 5.01	-	0.62	0.043	0.040	8.56 ± 7.1	6.83 ± 4.7	--	0.18	−0.18	0.6517	−0.05417
G38D	188053654	exon 2	G38D	G / A	0.019	9.04 ± 5.28	9.81 ± 4.33	-	0.76	−0.041	0.015	8.35 ± 6.9	7.99 ± 6.02	--	0.64	−0.10	0.604	−0.06676
R55C	188053704	exon 2	R55C	C / T	0.010	9.06 ± 5.01	1.20 ± 0.37	-	0.00030	−1.00	0.0046	8.37 ± 6.9	1.65 ± 0.7	--	0.0010	−1.40	1.016E-06	−1.17612
rs2241767	188053890	intron 2		A / G	0.028	9.06 ± 5.27	9.52 ± 5.26	-	0.31	0.087	0.044	8.51 ± 7.0	6.63 ± 4.8	2.51	0.035	−0.26	0.6792	−0.05886
rs3774262	188054508	intron 2		G / A	0.028	9.05 ± 5.26	9.52 ± 5.26	-	0.30	0.088	0.043	8.52 ± 7.0	6.49 ± 4.5	--	0.081	−0.22	0.8175	−0.04341
rs62625753	188054720	exon 3	G90S	G / A	0	9.01 ± 5.03	-	-	.	0	0.009	8.38 ± 6.9	20.83	--	0.065	1.12	0.06498	0.495953
rs17366743	188054783	exon 3	Y111H	T / C	0.010	9.02 ± 5.04	7.28 ± 4.04	-	0.35	−0.20	0.0056	8.40 ± 6.9	7.44 ± 4.3	--	0.72	−0.10	0.3382	−0.15459
rs7639352	188061168	3′		C / T	0.33	8.62 ± 4.67	9.18 ± 5.76	10.20 ± 4.94	0.026	0.072	0.33	8.46 ± 7.6	7.93 ± 6.0	8.18 ± 5.6	0.77	−0.015	0.1059	0.034991
rs1865762	188062094	3′		A / G	0.010	8.95 ± 5.00	11.50 ± 5.69	-	0.17	0.19	0.013	8.40 ± 7.0	6.41 ± 2.0	9.98	0.93	0.017	0.2622	0.11473
rs6444175	188062438	3′		G / A	0.33	8.74 ± 4.64	8.97 ± 5.33	10.21 ± 4.98	0.024	0.076	0.33	8.70 ± 7.8	7.96 ± 6.0	8.60 ± 5.8	0.79	−0.015	0.09874	0.037586
rs17373414	188068221	3′		C / T	0.020	8.96 ± 4.99	11.05 ± 6.10	-	0.47	0.10	0.025	8.28 ± 6.7	10.20 ± 9.4	2.51	0.46	0.11	0.3032	0.100109

^aBuild NCBI36/hg18;

^bmajor/minor alleles;

^cIRASFS, Insulin Resistance Atherosclerosis Family Study;

^dAA-DHS, African American Diabetes Heart Study;

^eMAF, minor allele frequency;

^f1 corresponds to the major allele and 2 corresponds to the minor allele;

^gmajor and minor alleles are different for IRASF-FS and AA-DHS cohorts, IRASFS alleles are listed;

^ha strict Bonferroni correction (n=18 tests) would set a significance threshold p-value<0.0028