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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Biochem J. 2013 Jul 1;453(1):49–60. doi: 10.1042/BJ20121598

Figure 8. A schematic representation of the proposed function of lipin1 in PPARγ regulation.

Figure 8

In the absence of exogenous PPARγ ligands, PPARγ recruits the corepressors NCoR1/SMRT. The mechanism of action of lipin1 involves triggering a conformational change in PPARγ causing co-repressor release and co-activator recruitment.