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. Author manuscript; available in PMC: 2013 Jun 23.
Published in final edited form as: Arthritis Rheum. 2012 Dec;64(12):3982–3992. doi: 10.1002/art.34645

Figure 4.

Figure 4

Histologic features and summed and maximal scores for structural damage in the mouse articular cartilage at 8 weeks following destabilization of the medial meniscus (DMM) surgery. A, Whole knee joints from Fgfr1 conditional knockout (cKO) and wild-type (WT) control mice were subjected to sham operation (left) or DMM surgery (right). The articular cartilage was stained with Safranin O–fast green at 8 weeks after surgery to assess the extent of articular cartilage degeneration. After DMM surgery, WT mice exhibited a loss of uncalcified cartilage and exposed subchondral bone (arrow), whereas Fgfr1 cKO mice showed reduced damage in the articular cartilage (arrowhead). Sham-operated knees showed no cartilage damage. Representative images are shown (n = 10 mice per genotype). Bar = 200 μm. B, Summed (top) and maximal (bottom) histologic scores of cartilage structure damage (mean ± SD) were determined in the medial femur and tibia of Fgfr1 cKO and WT mice at 8 weeks following sham operation or DMM surgery. ** = P < 0.001 versus WT.