Table 1.
Comparison of groups in terms of oxidant and antioxidants parameters in liver tissue.
| Groups | ||||
|---|---|---|---|---|
| CG n: 6 |
TG n: 6 |
TPG n: 6 |
HG n: 6 |
|
| MDA (µmol/g protein) | 11 ± 1.4 | 9 ± 0.5 P < 0.001* |
3 ± 0.5 P < 0.0001* |
2.2 ± 0.48 P < 0.0001* |
|
| ||||
| MPO (U/g protein) | 14 ± 2.1 | 12.5 ± 2.5 P > 0.05 |
4 ± 0.8 P < 0.0001* |
3.1 ± 0.6 P < 0.0001* |
|
| ||||
| tGSH (nmol/g protein) | 2 ± 0.7 | 2.8 ± 0.4 P < 0.05* |
7 ± 0.8 P < 0.0001* |
9 ± 0.6 P < 0.0001* |
|
| ||||
| GST (U/g protein) | 5 ± 1.5 | 6.4 ± 1.4 P > 0.05 |
14 ± 1.5 P < 0.0001* |
19 ± 1.9 P < 0.0001* |
|
| ||||
| GPx (U/g protein) | 7 ± 0.9 | 8.2 ± 0.7 P > 0.05 |
17 ± 0.6 P < 0.0001* |
18.7 ± 1.9 P < 0.0001* |
|
| ||||
| GR (U/g protein) | 3 ± 0.6 | 3.7 ± 0.5 P > 0.05 |
11 ± 1.5 P < 0.0001* |
14.5 ± 1.1 P < 0.0001* |
|
| ||||
| DNA damage product 8-OHGua/Gua (pmol/L) | 2.7 ± 0.4 | 2.5 ± 0.5 P > 0.05 |
1.1 ± 0.3 P < 0.0001* |
0.9 ± 0.3 P < 0.0001* |
*P ≤ 0.05 was significant. ANOVA post hoc—the least significant difference option was used. Group data were compared against the CG group.
Notes: data are mean ± standard deviation. CG: control group; TG: thiamine 20 mg/kg + cisplatin group; TPG: TPP 20 mg/kg + cisplatin group; CG: control group; MDA: malondialdehyde; MPO: myeloperoxidase; tGSH: total glutathione; GST: glutathione S-transferase; GPx: glutathione peroxidase; GR: glutathione reductase; n: number of animals.