Table 1.
Interventional studies (impact of periodontal therapy on systemic inflammatory biomarkers).
| Study | No. of patients | Type of study | Serum inflammatory biomarkers | Results |
|---|---|---|---|---|
| Ebersole et al., 1997 [52] | 34 pts/AP, 35 pts/ctrl |
Prospective/2 yrs interventional, SRP at every 6 mos + Fb (5,15 or 50 mg/b.i.d.) |
CRP, Hp | ↓ CRP, Hp at 2 yrs |
| D'Aiuto et al., 2004 [53] | 94 pts/SGP | Prospective/6 mos interventional, SPT (SRP) |
CRP, IL-6 | ↓ CRP, IL-6 at 6 mos |
| D'Aiuto et al., 2005 [54] | 65 pts/SGP | Prospective/2 mos interventional, IPT (SRP + Local Ab) |
CRP, IL-6, LDL chol total chol |
↓ CRP, IL-6, ↓ LDL chol ↓ total chol at 2 mos |
| D'Aiuto et al., 2006 [55] | 40 pts/SCGP | Prospective/6 mos interventional randomized SPT/IPT |
CRP, IL-6, total chol |
↓ CRP, IL-6 ↓ total chol at 2 and 6 mos in both groups but more important in the IPT group |
| Tonetti et al., 2007 [56] | 61 pts/SGP |
RCT/Prospective/6 mos interventional IPT |
CRP, IL-6 sE-selectin |
transient, acute, short-term ↑ CRP, IL-6 ↓ CRP at 6 mos ↓ sE-selectin |
| 59 pts/ctrl | SRP |
AP: adult periodontitis; SGP: severe generalized periodontitis; SCGP: severe chronic generalized periodontitis; SRP: scaling and root planning; SPT: standard periodontal therapy; IPT: intensive periodontal therapy; Fb: flurbiprofen; Ab: antibiotic; CRP: C-reactive protein; IL-6: interleukin-6; LDL chol: LDL cholesterol; Hp: haptoglobin; sE-selectin: soluble E selectin; yrs: years; and mos: months.