Table 4.

Performance of algorithms to identify cases and controls from EMRs for five primary phenotypes.

	GHC1	MCRF2	Mayo3	NU4	VU5
Primary Phenotype	Dementia	Cataract	Peripheral Arterial Disease	Type 2 diabetes	Cardiac conduction (Quantitative Trait)
EMR data sources to define phenotype	Diagnoses, Medications	Diagnoses, Procedures, Medications	Procedure Reports	Diagnoses, Laboratory Tests, Medications	Diagnoses, Laboratory Tests, Medications, ECG Results
Method to validate EMR phenotype	Physician Review*	Trained Chart Reviewers	Compared to Clinical Gold Standard	Physician Review	Physician Review
Number of Cases/Controls	747/2043	2642/1322	1679/1657	756/777	2950
Biospecimen #	2790	19771	3336	8161	81952
% of total biospecimen pool	26.8%	13.4%	50.3%	9.3%	3.6%
PPV (case/control)	73%	98%/98%	94%/99%	98%/100%	97%

^*Review team included two physicians, a psychometrician, a neuropsychologist, and a study nurse

¹Group Health Cooperative

²Marshfield Clinic Research Foundation

³Mayo Clinic

⁴Northwestern University

⁵Vanderbilt University