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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 13;56(10):4125–4129. doi: 10.1021/jm400397x

Scheme 1. Synthesis of advanced aniline intermediate 4.a.

Scheme 1

aReagents and conditions: (a) TBSOTf, 2,6-lutidine, CH2Cl2; (b) TBAF, AcOH, THF; (c) 1,4-benzodioxan-6-sulfonyl chloride, 2,6-lutidine, CH2Cl2, 74% yield (3 steps); (d) H2, Pd/C, EtOH, 91% yield.