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. Author manuscript; available in PMC: 2014 May 23.
Published in final edited form as: J Med Chem. 2013 May 13;56(10):4125–4129. doi: 10.1021/jm400397x

Scheme 2. General synthesis of compound 1 and urea analogs.a.

Scheme 2

aReagents and conditions: (a) diphosgene (ClCO2CCl3), proton sponge, CH2Cl2, 96% yield; (b) R2NH, PhMe, 36–99% yield; (c) DDQ, pH 7.4 buffer, CH2Cl2, 63% and 50% yield (for 1 and 7b, respectively); (d) TFA, CH2Cl2, 44–87% yield (for 7a,c–i).