Table I.
Genotype (n) |
Plasma Cholesterol (mg/dL) |
Plasma Triglycerides (mg/dL) |
Human Wild-type ApoA-I (mg/dL) |
Human L159R ApoA-I (mg/dL) |
Mouse ApoE (mg/dL) |
---|---|---|---|---|---|
CHOW | |||||
DKO (10) | 190 ± 19a | 126 ± 26a | - | - | 7 ± 2a |
WT-DKO (53) | 195 ± 8a | 98 ± 8a | 100 ± 6a | - | 5 ± 1a |
FIN-DKO (37) | 200 ± 13a | 120 ± 10a | - | 5 ± 1a | 17 ± 3b |
WT FIN-DKO (24) | 169 ± 5a | 86 ± 5b | 113 ± 10a | 25 ± 2b | 10 ± 2a,b |
DIET | |||||
DKO (24) | 710 ± 19a | 226 ± 53a | - | - | 22 ± 2b |
WT-DKO (15) | 1201 ± 68b | 347 ± 51a | 126 ± 16a | - | 21 ± 3b |
FIN-DKO (23) | 750 ± 32a | 265 ± 14a | - | 9 ± 2a | 36 ± 2c |
WT FIN-DKO (9) | 850 ± 46c | 375 ± 55a | 129 ± 19a | 38 ± 5c | 48 ± 3c |
Plasma cholesterol, triglyceride and apolipoprotein values were determined as described in “Materials and Methods.” All values represent the mean ± SD. The number of animals analyzed for each genotype is shown in parenthesis. No statistically significant differences between genders were noted among any of the 4 genotypes. Superscripts with different letters indicate significant differences at ρ < 0.05.