Table 2.

Multivariate analysis: Predictors of life threatening cardiac events.

	Hazard ratio	95% CI	P Value
Multiple mutations vs. single mutation*	2.28	1.17–4.42	0.015
Multiple mutations in single gene vs. single mutation	3.15	1.30–7.61	0.010
Multiple mutations involving different genes vs. single mutation	1.68	0.69–4.11	0.256
Female	2.25	1.01–5.02	0.048
QTc ≥ 500msec	2.22	1.04–4.74	0.041

Models were adjusted also for time dependent beta blockers, and QTc missing.

^*The effects of multiple mutations in single gene and in multiple genes were assessed in a separate model.