Table 3.
Effect estimates (ORs and 95% CI) for ambient residential or workplace exposure to diazinon, chlorpyrifos and parathion and Parkinson’s disease by PON1Q192R genotype, Caucasians only
| PON1-192 RR+QR | PON1-192 QQ | |||||
|---|---|---|---|---|---|---|
| Exposure | No. cases/controls |
Crude OR | Adjusted OR (95% CI)a |
No. cases/controls |
Crude OR | Adjusted OR (95% CI)a |
| Ambient Residential or Workplace Exposureb | ||||||
| Diazinon | ||||||
| Zero Exposure | 33/69 | 1.00 | 1.00 | 32/59 | 1.13 | 1.14 (0.62–2.09) |
| Low/High Exposure | 89/124 | 1.50 | 1.33 (0.78–2.26) | 91/107 | 1.78 | 1.53 (0.90–2.61) |
| Chlorpyrifos | ||||||
| Zero Exposure | 33/69 | 1.00 | 1.00 | 32/59 | 1.13 | 1.14 (0.62–2.09) |
| Low/High Exposure | 73/100 | 1.53 | 1.48 (0.86–2.56) | 83/82 | 2.12 | 1.95 (1.13–3.37) |
| Parathion | ||||||
| Zero Exposure | 33/69 | 1.00 | 1.00 | 32/59 | 1.13 | 1.13 (0.62–2.08) |
| Low/High Exposure | 77/109 | 1.48 | 1.34 (0.78–2.32) | 77/82 | 1.96 | 1.65 (0.95–2.89) |
a
adjusted for age, gender, smoking status, county, and education level
b
reference group of participants is for those unexposed to all three OPs