Table 2.
Adjusted odds ratios and 95% confidence intervals for the association between quartiles of UV radiation exposure based on mother’s address at birth and cancer in offspring ages 0–5 in California (1986–2007)
Adjusted for birth year (controls n=207308) | Adjusted for mother’s age, race, and child’s birth year (controls n=203018) | |||||||
---|---|---|---|---|---|---|---|---|
| ||||||||
Cancer | UV quartilesa (Watt hrs/m2) | Cases (n) | OR | 95 %CI | Cases (n) | OR | 95 %CI | Trend p-value |
ALL | 3396 | 3324 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.93 | (0.85, 1.03) | 0.91 | (0.83, 1.01) | ||||
Q3 | 1.03 | (0.94, 1.13) | 0.97 | (0.88, 1.07) | ||||
Q4 | 0.93 | (0.84, 1.02) | 0.89 | (0.81, 0.99) | 0.042 | |||
AML | 565 | 552 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.99 | (0.78, 1.24) | 1.00 | (0.79, 1.26) | ||||
Q3 | 1.02 | (0.81, 1.29) | 1.00 | (0.79, 1.27) | ||||
Q4 | 0.87 | (0.69, 1.11) | 0.90 | (0.70, 1.15) | 0.447 | |||
Astrocytoma | 801 | 789 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.82 | (0.67, 1.00) | 0.91 | (0.75, 1.12) | ||||
Q3 | 0.83 | (0.68, 1.01) | 0.92 | (0.75, 1.12) | ||||
Q4 | 0.92 | (0.76, 1.11) | 0.96 | (0.79, 1.17) | 0.648 | |||
Bone tumors | 79 | 78 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.83 | (0.41, 1.67) | 0.80 | (0.39, 1.65) | ||||
Q3 | 1.47 | (0.80, 2.73) | 1.37 | (0.73, 2.57) | ||||
Q4 | 1.37 | (0.73, 2.57) | 1.22 | (0.64, 2.32) | 0.411 | |||
Other gliomas | 220 | 217 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.93 | (0.65, 1.33) | 0.99 | (0.68, 1.43) | ||||
Q3 | 0.80 | (0.55, 1.16) | 0.90 | (0.61, 1.32) | ||||
Q4 | 0.82 | (0.57, 1.19) | 0.91 | (0.62, 1.32) | 0.568 | |||
Ependymoma and choroid plexus tumors | 244 | 241 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.04 | (0.74, 1.46) | 1.08 | (0.76, 1.53) | ||||
Q3 | 0.89 | (0.63, 1.27) | 0.92 | (0.64, 1.33) | ||||
Q4 | 0.84 | (0.59, 1.21) | 0.88 | (0.61, 1.27) | 0.465 | |||
Hepatoblastoma | 258 | 256 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.95 | (0.69, 1.32) | 0.95 | (0.68, 1.32) | ||||
Q3 | 0.85 | (0.61, 1.19) | 0.82 | (0.58, 1.16) | ||||
Q4 | 0.7 | (0.49, 1.00) | 0.69 | (0.48, 1.00) | 0.044 | |||
Hodgkin’s lymphoma | 62 | 62 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.19 | (0.51, 2.75) | 0.90 | (0.38, 2.10) | ||||
Q3 | 2.33 | (1.11, 4.89) | 1.72 | (0.81, 3.66) | ||||
Q4 | 1.7 | (0.78, 3.71) | 1.32 | (0.60, 2.92) | 0.345 | |||
Non-Hodgkin’s lymphoma | 271 | 268 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.80 | (0.57, 1.12) | 0.84 | (0.60, 1.18) | ||||
Q3 | 1.01 | (0.73, 1.38) | 1.05 | (0.76, 1.45) | ||||
Q4 | 0.72 | (0.51, 1.01) | 0.71 | (0.50, 1.02) | 0.119 | |||
Intracranial and intraspinal embryonal tumors | 559 | 550 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.19 | (0.94, 1.52) | 1.26 | (0.98, 1.61) | ||||
Q3 | 1.14 | (0.89, 1.45) | 1.20 | (0.93, 1.54) | ||||
Q4 | 1.26 | (1.00, 1.61) | 1.29 | (1.01, 1.65) | 0.047 | |||
Other intracranial and intraspinal neoplasms | 113 | 108 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.82 | (0.48, 1.39) | 0.95 | (0.55, 1.66) | ||||
Q3 | 0.93 | (0.56, 1.55) | 1.05 | (0.62, 1.80) | ||||
Q4 | 0.92 | (0.55, 1.54) | 1.05 | (0.61, 1.79) | 0.839 | |||
Neuroblastoma | 1070 | 1042 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.81 | (0.68, 0.96) | 0.90 | (0.76, 1.07) | ||||
Q3 | 0.81 | (0.68, 0.95) | 0.91 | (0.77, 1.09) | ||||
Q4 | 0.87 | (0.74, 1.03) | 0.93 | (0.79, 1.11) | 0.385 | |||
Rhabdomyosarcoma | 364 | 352 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.17 | (0.89, 1.55) | 1.22 | (0.91, 1.63) | ||||
Q3 | 0.92 | (0.68, 1.23) | 1.01 | (0.74, 1.37) | ||||
Q4 | 0.88 | (0.65, 1.19) | 0.97 | (0.71, 1.33) | 0.804 | |||
Other soft tissue sarcomas | 140 | 136 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.14 | (0.69, 1.90) | 1.08 | (0.64, 1.82) | ||||
Q3 | 1.54 | (0.96, 2.48) | 1.49 | (0.92, 2.43) | ||||
Q4 | 1.33 | (0.82, 2.18) | 1.26 | (0.77, 2.09) | 0.260 | |||
Wilms’ tumor | 824 | 812 | ||||||
Q1 | ref | ref | ||||||
Q2 | 0.90 | (0.75, 1.09) | 0.91 | (0.75, 1.11) | ||||
Q3 | 0.83 | (0.68, 1.00) | 0.87 | (0.71, 1.06) | ||||
Q4 | 0.91 | (0.75, 1.09) | 0.92 | (0.76, 1.12) | 0.335 | |||
Germ cell tumors | 370 | 363 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.10 | (0.83, 1.46) | 1.17 | (0.88, 1.57) | ||||
Q3 | 1.12 | (0.85, 1.49) | 1.17 | (0.87, 1.56) | ||||
Q4 | 0.86 | (0.63, 1.16) | 0.9 | (0.66, 1.23) | 0.666 | |||
Retinoblastoma | 606 | 591 | ||||||
Q1 | ref | ref | ||||||
Q2 | 1.02 | (0.81, 1.27) | 1.03 | (0.82, 1.30) | ||||
Q3 | 1.008 | (0.81, 1.26) | 1.03 | (0.82, 1.30) | ||||
Q4 | 0.877 | (0.70, 1.10) | 0.88 | (0.69, 1.11) | 0.338 |
Q1: 3133 – 4946; Q2: >4946 – 5030; Q3: >5030 – 5111; Q4: >5111 – 5804 Watt-hrs/m2.